Effect of Perioperative Continuous Intravenous Infusion of Lidocaine on Postoperative Pain and Long-term Survival in Elderly Patients Undergoing Colorectal Cancer Surgery: a Prospective, Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study is a further observation and follow-up of the patients enrolled in the registration number NCT05920980 to further evaluate the effect of long-term infusion of lidocaine on postoperative chronic pain, long-term quality of life and survival rate in patients undergoing colorectal cancer surgery.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: f
View:
• Participants were at least 60 years old;
• American Society of Anesthesiologists (ASA) physical status I to III;
• Body-mass index of 18-30 kg/m2;
• Scheduled for elective colorectal surgery.
Locations
Other Locations
China
China
RECRUITING
Sichuan
Contact Information
Primary
Chunling Jiang, PhD
jiang_chunling@yahoo.com
18980601096
Backup
Qian Li, PhD
jiang_chunling@yahoo.com
18980601096
Time Frame
Start Date: 2023-06-05
Estimated Completion Date: 2027-06-01
Participants
Target number of participants: 276
Treatments
Experimental: Lidocaine group
Patients in the lidocaine group, lidocaine 1.5mg/kg/h is continuously infused (using ideal body weight) during the whole procedure, postoperative analgesia pump with lidocaine (lidocaine 50mg/kg, sufentanil 2ug/kg, glassetron 12mg) diluted to 200ml with saline until 72h after surgery.
Placebo_comparator: Placebo group
In the placebo group, the same volume of normal saline will be administered during anesthesia. The postoperative PCIA device will contain sufentanil 2μg/kg, granisetron 12mg diluted to 200 mL in 0.9% normal saline solution with a total volume of 200 mL.
Related Therapeutic Areas
Sponsors
Leads: West China Hospital